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“For equine dermatology, it all comes down to one product. Zarasyl.”

Nearly a decade of scientific research has been conducted to perfect the patented technology contained in Zarasyl Equine Barrier Cream. Zarasyl leverages the novel technology of amorphous silica nanoparticles (SNP)  which are known to be effective delivery vehicles for orthosilicic acid (OSA, Si(OH)4), the bioavailable form of silicon that favors wound healing. OSA reportedly accelerates wound cicatrisation by stimulating basal epidermal and dermal fibroblast cells to up-regulate expression of basic fibroblast growth factor (β-FGF). Moreover, collagen and elastin fibers formed in the presence of OSA are more densely packed, better organized and more homogenously distributed, possibly due to activation of hydroxylation enzymes.

Experimental models have shown that OSA interacts with collagen through coulombic hydrogen bonding, this interaction being strongest at pH5. Additionally, prior to dissolution into OSA, the SNP appear to stimulate fibroblast proliferation and migration directly. Moreover, SNP of the size and chemical character employed in Zarasyl stimulate T lymphocytes (T cells) which are key regulators of responses to skin injury. When activated, these cells proliferate and secrete regulatory molecules such as growth factors and cytokines to stimulate production of new epithelial cells in the vicinity of the injury. They also recruit additional immune cells to the wounded area and activate other responses to skin injury such as production of anti-microbial defense proteins. 

Also contained in Zarasyl’s formula is PEG 400. PEG 400 is a topical disinfecting agent that, in general, works by drawing water from bacterial cells. Additionally, it exhibits specific antibacterial activity against gram-negative bacteria. It is effective for management of inflammatory skin disease, scar tissue formation and enhancing the repair of damaged skin, mucosa or wounds.

Zarasyl is steroid and antibiotic free. 

“Developed by top scientists. Recommended by top veterinarians.”

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